(RS) - (Tetrazol-5-yl) glycine

(RS) - (Tetrazol-5-yl) glycine (D, L- (tetrazol-5-yl) glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS) - (Tetrazol-5-yl) glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS) - (Tetrazol-5-yl) glycine induces seizure responses and Fos in mice[3].

Product Specifications

CAS Number

[138199-51-6]

Product Name Alternative

D, L- (tetrazol-5-yl) glycine; LY 285265

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

96.53

Solubility

H2O : 5 mg/mL (ultrasonic)

Smiles

O=C(O)C(N)C1=NNN=N1

Molecular Formula

C3H5N5O2

Molecular Weight

143.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Schoepp DD, et al. D, L- (tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. Eur J Pharmacol. 1991 Oct 15;203 (2) :237-43.|[2]Vance KM, et al. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun. 2011;2:294.|[3]Duncan GE, et al. Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl) glycine in a geneticmodel of NMDA receptor hypofunction. Brain Res. 2008 Jul 24;1221:41-8.|[4]Ong WY, et al. P2 purinoceptor blocker suramin antagonises NMDA receptors and protects against excitatory behaviour caused by NMDA receptor agonist (RS) - (tetrazol-5-yl) -glycine in rats. J Neurosci Res. 1997 Sep 1;49 (5) :627-38.