YM-58483 (Standard)
YM-58483 (Standard) is the analytical standard of YM-58483. This product is intended for research and analytical applications. YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE) [1][2].
Product Specifications
CAS Number
223499-30-7
Product Name Alternative
BTP2 (Standard)
UNSPSC
12352005
Target
CRAC Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2
Molecular Formula
C15H9F6N5OS
Molecular Weight
421.32
References & Citations
[1]Qi Z, et al. The Central Analgesic Mechanism of YM-58483 in Attenuating Neuropathic Pain in Rats. Cell Mol Neurobiol. 2016 Oct;36 (7) :1035-43|[2]Ohga K, et al. Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo. Int Immunopharmacol. 2008 Dec 20;8 (13-14) :1787-9|[3]Ohga K, et al. The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo. Pulm Pharmacol Ther. 2008;21 (2) :360-9|[4]Yoshino T, et al. YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. Eur J Pharmacol. 2007 Apr 10;560 (2-3) :225-33
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-B410840-5MG 5 mg
5,7-Bis-(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one
Sign In for Pricing
View Details 
BNC470419-100 1x 100 µL
Transglutaminase II (TGM2/419), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 