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NCB-0846 (Standard)

NCB-0846 (Standard) is the analytical standard of NCB-0846. This product is intended for research and analytical applications. NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation[1][2].

Product Specifications

CAS Number

1792999-26-8

Target

MAP4K; Reference Standards; TGF-beta/Smad; Wnt

Related Pathways

MAPK/ERK Pathway; Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

O[C@@H](CC1)CC[C@@H]1OC2=CC=CC(C=N3)=C2N=C3NC4=CC=C(N=CN5)C5=C4

Molecular Formula

C21H21N5O2

Molecular Weight

375.42

References & Citations

[1]Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586.|[2]Sugano T, et al., Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846. Br J Cancer. 2021 Jan;124 (1) :228-236.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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