Triapine (Standard)
Triapine (Standard) is the analytical standard of Triapine. This product is intended for research and analytical applications. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
Product Specifications
CAS Number
143621-35-6
Target
DNA/RNA Synthesis; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
S=C(N)N/N=C/C1=NC=CC=C1N
Molecular Formula
C7H9N5S
Molecular Weight
195.24
References & Citations
[1]Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84 (4) :e475-81.|[2]Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84 (1) :52-8.|[3]Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103 (40) :14901-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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