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(R) - (+) -HA-966 (Standard)

(R) - (+) -HA-966 (Standard) is the analytical standard of (R) - (+) -HA-966. This product is intended for research and analytical applications. (R) - (+) -HA-966 ((+) -HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R) - (+) -HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine[1][2]. (R) - (+) -HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain[3].

Product Specifications

CAS Number

123931-04-4

Target

IGluR; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

O=C1N(O)CC[C@H]1N

Molecular Formula

C4H8N2O2

Molecular Weight

116.12

References & Citations

[1]Hutson PH, et al. R- (+) -HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol. 1991 Aug;103 (4) :2037-44.|[2]Witkin JM, et al. Discriminative stimulus effects of R- (+) -3-amino-1-hydroxypyrrolid-2-one, [ (+) -HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275 (3) :1267-73.|[3]Christensen D, et al. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+) -HA966 in a rat model of peripheral neuropathy. Br J Pharmacol. 1998 Dec;125 (8) :1641-50.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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