RO5234444
RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy[1].
Product Specifications
CAS Number
1365266-79-0
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Metabolic Disease
Smiles
O=C1N(CCCN(CC2)C[C@@H](O)C32CC3)CCN(C(/C=C/C4=CC=C(F)C(Cl)=C4)=O)[C@H]1C
Molecular Formula
C24H31ClFN3O3
Molecular Weight
463.97
References & Citations
[1]Sayyed SG, et al. An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes. Kidney Int. 2011 Jul;80 (1) :68-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2
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