Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Saclofen (Standard)

Saclofen (Standard) is the analytical standard of Saclofen. This product is intended for research and analytical applications. Saclofen is an orally available competitive GABAB receptor antagonist with an IC50 of 7.8 μM, but it has a weaker antagonistic effect on GABAB1b and GABAB2 heterodimer recombinant receptors. Saclofen can inhibit the binding of baclofen to rat cerebellar membranes and block the phase shifts in circadian rhythms caused by baclofen. Saclofen has also shown anti-inflammatory and analgesic effects in rats[1][2][3][4][5].

Product Specifications

CAS Number

125464-42-8

UNSPSC

12352005

Target

GABA Receptor; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=S(CC(CN)C1=CC=C(Cl)C=C1)(O)=O

Molecular Formula

C9H12ClNO3S

Molecular Weight

249.72

References & Citations

[1]Sallam MY, et al. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389 (3) :279-88. |[2]K R Biggs, et al. GABAB receptor stimulation phase-shifts the mammalian circadian clock in vitro. Brain Res. 1998 Oct 5;807 (1-2) :250-4.|[3]M D Wood, et al. The human GABA (B1b) and GABA (B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000 Nov;131 (6) :1050-4.|[4]Seyyed Hamid Bathaei, et al. The Effect of Flavonoids Catechin, Baclofen and Saclofen on Acetic Acid - Induced Visceral Pain by in Rat. International Journal of Pharmaceutical Research & Allied Sciences. 2016, 5 (1) :81-85|[5]C A Drew, et al. Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists. Neurosci Lett. 1990 May 18;113 (1) :107-10.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Rabbit anti-PFKP Antibody, Affinity Purified
A304-284A-T 10 µg

Rabbit anti-PFKP Antibody, Affinity Purified

Sign In for Pricing
View Details
Foxp3 (NM_001108250) Rat Untagged Clone
RN214229 10 µg

Foxp3 (NM_001108250) Rat Untagged Clone

Sign In for Pricing
View Details
Recombinant Human DNA Polymerase lambda Protein
NBP1-72496-250ug 250 µg

Recombinant Human DNA Polymerase lambda Protein

Sign In for Pricing
View Details
Lentiviral mouse 9130401M01Rik shRNA (UAS) - Lentiviral mouse 9130401M01Rik shRNA (UAS, iRFP) (100)
GTR15172347 1 Vial

Lentiviral mouse 9130401M01Rik shRNA (UAS) - Lentiviral mouse 9130401M01Rik shRNA (UAS, iRFP) (100)

Sign In for Pricing
View Details
Polyclonal Antibody to Retinol Binding Protein 5, Cellular (RBP5)
TRV-0040270-01 20 µL

Polyclonal Antibody to Retinol Binding Protein 5, Cellular (RBP5)

Sign In for Pricing
View Details
Polyclonal Antibody to Retinol Binding Protein 5, Cellular (RBP5)
TRV-0040270-02 100 µL

Polyclonal Antibody to Retinol Binding Protein 5, Cellular (RBP5)

Sign In for Pricing
View Details