TACA (Standard)
TACA (Standard) is the analytical standard of TACA (HY-100800) . This product is intended for research and analytical applications. TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM) . TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons[1][2][3].
Product Specifications
CAS Number
[38090-53-8]
Target
GABA Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(O)/C=C/CN
Molecular Formula
C4H7NO2
Molecular Weight
101.10
References & Citations
[1]Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122 (8) :1551-1560.|[2]Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82 (3) :1489-1496.|[3]Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24 (1) :157-160.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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