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2-PMPA (Standard)

2-PMPA (Standard) is the analytical standard of 2-PMPA. This product is intended for research and analytical applications. 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.

Product Specifications

CAS Number

173039-10-6

Product Name Alternative

2- (Phosphonomethyl) pentanedioic acid (Standard)

UNSPSC

12352211

Target

Carboxypeptidase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Neurological Disease

Smiles

O=C(O)C(CP(O)(O)=O)CCC(O)=O

Molecular Formula

C6H11O7P

Molecular Weight

226.12

References & Citations

[1]Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) . J Pharm Biomed Anal. 2014 Jan;88:162-9.|[2]Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.|[3]Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26 (1) :1-15.|[4]Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51 (7-8) :1163-71.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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