Dihydrokainic acid (Standard)

Dihydrokainic acid (Standard) is the analytical standard of Dihydrokainic acid. This product is intended for research and analytical applications. Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1].

Product Specifications

CAS Number

[52497-36-6]

UNSPSC

12352005

Target

EAAT; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Neurological Disease

Smiles

O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)C

Molecular Formula

C10H17NO4

Molecular Weight

215.25

References & Citations

[1]Lehmann A, et al. Dihydrokainic acid affects extracellular taurine and phosphoethanolamine levels in the hippocampus. Neuroscience Letters, 1983, 38 (1) : 67-72. |[2]Bouazzaoui M, et al. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Neurochem Res. 1996 Dec;21 (12) :1527-33.|[3]Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27 (4) :375-81.|[4]Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32.|[5]Muñoz M D, et al. Effects of dihydrokainic acid of extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology, 1987, 26 (1) : 1-8.