(2R,5S) -Ritlecitinib (Standard)
(2R,5S) -Ritlecitinib (Standard) is the analytical standard of (2R,5S) -Ritlecitinib. This product is intended for research and analytical applications. (2R,5S) -Ritlecitinib (2R,5S) -PF-06651600) is a JAK3 inhibitor (IC50=144.8 nM)[2].
Product Specifications
CAS Number
1792180-79-0
Target
JAK; Reference Standards
Related Pathways
Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
C[C@@H]1CC[C@@H](CN1C(C=C)=O)NC2=C3C=CNC3=NC=N2
Molecular Formula
C15H19N5O
Molecular Weight
285.35
References & Citations
[1]Matthew Frank, et al. Pyrrolo[2,3-d]pyrimidinyl-, pyrrolo[2,3-b]pyrazinyl-and pyrrolo[2,3-d]pyridinylacrylamides as JAK inhibitor and their preparation. World Intellectual Property Organization, WO2015083028 A1 2015-06-11.|[2]Thorarensen A, et al. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1- ((2 S, 5 R) -5- ((7 H-Pyrrolo [2, 3-d] pyrimidin-4-yl) amino) -2-methylpiperidin-1-yl) prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. Journal of medicinal chemistry, 2017, 60 (5) : 1971-1993.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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