TPCA-1 (Standard)
TPCA-1 (Standard) is the analytical standard of TPCA-1 (HY-10074) . This product is intended for research and analytical applications. TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.
Product Specifications
CAS Number
[507475-17-4]
Target
Apoptosis; IKK; Reference Standards; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; NF-κB; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Cancer
Smiles
O=C(C1=C(NC(N)=O)SC(C2=CC=C(F)C=C2)=C1)N
Molecular Formula
C12H10FN3O2S
Molecular Weight
279.29
References & Citations
[1]Sachse F, et al. IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.Rhinology. 2011 Jun;49 (2) :168-73.|[2]Podolin PL, et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[ (aminocarbonyl) amino]-5- (4-fluorophenyl) -3-thiophenecarboxamide), occurs via reduction of proinflamm|[3]Nan J, et al. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Mol Cancer Ther. 2014 Mar;13 (3) :617-29.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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