GNE-140 (racemate) (Standard)
GNE-140 (racemate) (Standard) is the analytical standard of GNE-140 (racemate). This product is intended for research and analytical applications. GNE-140 racemate is a racemate mixture of (R) -GNE-140 and (S) -GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].
Product Specifications
CAS Number
1802977-61-2
Target
Lactate Dehydrogenase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O
Molecular Formula
C25H23ClN2O3S2
Molecular Weight
499.04
References & Citations
[1]Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7 (10) :896-901.|[2] Ždralević M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293 (41) :15947-15961.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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