(R) -GNE-140 (Standard)
(R) -GNE-140 (Standard) is the analytical standard of (R) -GNE-140 (HY-100742A) . This product is intended for research and analytical applications. (R) -GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R) -GNE-140 is 18-fold more potent than S enantiomer.
Product Specifications
CAS Number
[2003234-63-5]
Target
Lactate Dehydrogenase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C1N[C@@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl
Molecular Formula
C25H23ClN2O3S2
Molecular Weight
499.04
References & Citations
[1]Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7 (10) :896-901.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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