(1α,1'S,4β) -Lanabecestat (Standard)

(1α,1'S,4β) -Lanabecestat (Standard) is the analytical standard of (1α,1'S,4β) -Lanabecestat (HY-100740C) . This product is intended for research and analytical applications. (1α,1'S,4β) -Lanabecestat ((1α,1'S,4β) -AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM[1].

Product Specifications

CAS Number

[1384082-96-5]

Target

Beta-secretase; Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

NC(C(C)=N1)=N[C@]21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[C@]52CC[C@@H](OC)CC5

Molecular Formula

C26H28N4O

Molecular Weight

412.53

References & Citations

[1]Eketjäll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50 (4) :1109-23.