(1α,1'S,4β) -Lanabecestat (Standard)
(1α,1'S,4β) -Lanabecestat (Standard) is the analytical standard of (1α,1'S,4β) -Lanabecestat. This product is intended for research and analytical applications. (1α,1'S,4β) -Lanabecestat ((1α,1'S,4β) -AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM[1].
Product Specifications
CAS Number
1384082-96-5
Target
Beta-secretase; Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
NC(C(C)=N1)=N[C@]21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[C@]52CC[C@@H](OC)CC5
Molecular Formula
C26H28N4O
Molecular Weight
412.53
References & Citations
[1]Eketjäll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50 (4) :1109-23.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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