ML349 (Standard)

ML349 (Standard) is the analytical standard of ML349 (HY-100737) . This product is intended for research and analytical applications. ML349 is a potent and specific acyl protein thioesterase 2 (APT2) /lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2].

Product Specifications

CAS Number

[890819-86-0]

Target

Phospholipase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1

Molecular Formula

C23H22N2O4S2

Molecular Weight

454.56

References & Citations

[1]Won SJ, et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2) . ACS Chem Biol. 2016 Dec 16;11 (12) :3374-3382.|[2]Adibekian A, et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) .|[3]Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7 (6) :7297-306.