C 87 (Standard)

C 87 (Standard) is the analytical standard of C 87 (HY-100735) . This product is intended for research and analytical applications. C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.

Product Specifications

CAS Number

[332420-90-3]

Target

Reference Standards; TNF Receptor

Related Pathways

Apoptosis; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C4=CC=CC=C4)C3=N\NC5=CC=C(Cl)C([N+]([O-])=O)=C5

Molecular Formula

C24H15ClN6O3S

Molecular Weight

502.93

References & Citations

[1]Ma L, et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 2014 May 2;289 (18) :12457-66.