SPC 839 (Standard)

SPC 839 (Standard) is the analytical standard of SPC 839 (HY-10072) . This product is intended for research and analytical applications. SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].

Product Specifications

CAS Number

[219773-55-4]

Target

AP-1; NF-κB; Reference Standards

Related Pathways

Immunology/Inflammation; NF-κB; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(C(C)=C1)N(NC2=C(C(OC)=CC=C3)C3=NC(C4=CC=CS4)=N2)C1=O

Molecular Formula

C18H14N4O3S

Molecular Weight

366.39

References & Citations

[1]Moorthy S S Palanki, et al. The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies. Bioorg Med Chem Lett. 2003 Nov 17;13 (22) :4077-80.