GNE-272 (Standard)
GNE-272 (Standard) is the analytical standard of GNE-272. This product is intended for research and analytical applications. GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively. GNE-272 is also a selective in vivo probe for CBP/EP300[1].
Product Specifications
CAS Number
1936428-93-1
Target
Epigenetic Reader Domain; Histone Acetyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
CC(N1CCC2=C(C(NC3=C(F)C=C(C4=CN(C)N=C4)C=C3)=NN2[C@@H]5COCC5)C1)=O
Molecular Formula
C22H25FN6O2
Molecular Weight
424.47
References & Citations
[1]Crawford TD, et al. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. J Med Chem. 2016 Dec 8;59 (23) :10549-10563.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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