BM212 (Standard)
BM212 (Standard) is the analytical standard of BM212. This product is intended for research and analytical applications. BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM[1][2].
Product Specifications
CAS Number
146204-42-4
UNSPSC
12352005
Target
Bacterial; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
CN1CCN(CC2=C(C)N(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)=C2)CC1
Molecular Formula
C23H25Cl2N3
Molecular Weight
414.37
References & Citations
[1]Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8 (2) |[2]Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42 (11) :3035-7.|[3]Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5 (6) :944-953.|[4]Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42 (11) :3035-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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