GC376 (sodium) (Standard)
GC376 (sodium) (Standard) is the analytical standard of GC376 (sodium) (HY-100721) . This product is intended for research and analytical applications. GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively.
Product Specifications
CAS Number
[1416992-39-6]
Target
Reference Standards; Virus Protease
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@](C(S(=O)(O[Na])=O)O)([H])CC1C(NCC1)=O)=O)OCC2=CC=CC=C2
Molecular Formula
C21H30N3NaO8S
Molecular Weight
507.53
References & Citations
[1]Kim Y, et al. Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. J Virol. 2012 Nov;86 (21) :11754-62.|[2]Takahashi D, et al. Structural and inhibitor studies of norovirus 3C-like proteases. Virus Res. 2013 Dec 26;178 (2) :437-44.|[3]Yunjeong Kim, et al. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016 Mar 30;12 (3) :e1005531.|[4]Pedersen NC, et al. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. J Feline Med Surg. 2017 Sep 1:1098612X17729626.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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