GSK2193874 (Standard)
GSK2193874 (Standard) is the analytical standard of GSK2193874. This product is intended for research and analytical applications. GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50s of 2 nM and 40 nM for rTRPV4 and hTRPV4[1].
Product Specifications
CAS Number
1336960-13-4
Target
Reference Standards; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(CN2CCC(N3CCCCC3)CC2)C(C4=CC=CC(C(F)(F)F)=C4)=NC5=CC(Br)=CC=C15)NC6(C7=CC=CC=C7)CC6
Molecular Formula
C37H38BrF3N4O
Molecular Weight
691.62
References & Citations
[1]Cheung M, et al. Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4. ACS Med Chem Lett. 2017 Mar 20;8 (5) :549-554.|[2]Thorneloe KS, et al. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med. 2012 Nov 7;4 (159) :159ra148.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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