BRD-6929 (Standard)

BRD-6929 (Standard) is the analytical standard of BRD-6929 (HY-100719) . This product is intended for research and analytical applications. BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3].

Product Specifications

CAS Number

[849234-64-6]

Target

HDAC; HIV; Reference Standards

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Infection; Cardiovascular Disease

Smiles

O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

Molecular Formula

C19H17N3O2S

Molecular Weight

351.42

References & Citations

[1]Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147|[2]Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8 (8) :e71323.|[3]Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9 (3) :268-273.