D-AP5 (Standard)
D-AP5 (Standard) is the analytical standard of D-AP5. This product is intended for research and analytical applications. D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].
Product Specifications
CAS Number
79055-68-8
Target
IGluR; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
N[C@H](CCCP(O)(O)=O)C(O)=O
Molecular Formula
C5H12NO5P
Molecular Weight
197.13
References & Citations
[1]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12 (1) :21-34.|[2]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37 (5) :700-17.|[3]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75 (1) :65-75.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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