DPO-1 (Standard)

DPO-1 (Standard) is the analytical standard of DPO-1 (HY-100712) . This product is intended for research and analytical applications. DPO-1 is a potent Kv1.5 and Kv1.3 (EC50 = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca2+ influx in Ca2+-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU) -induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K+ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation[1][2][3].

Product Specifications

CAS Number

[43077-30-1]

Target

Calcium Channel; Interleukin Related; NOD-like Receptor (NLR) ; Potassium Channel; Reference Standards

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Smiles

CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C

Molecular Formula

C22H29OP

Molecular Weight

340.44

References & Citations

[1]Tsvetkov D, et al. The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of Vascular Tone. Front Physiol. 2016 Aug 4;7:335. |[2]Zhao N, et al. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS One. 2013 May 22;8 (5) :e64629.|[3]Li P, et al. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Mol Biol Rep. 2022 Jul;49 (7) :5939-5952.