Y-33075 (dihydrochloride) (Standard)
Y-33075 (dihydrochloride) (Standard) is the analytical standard of Y-33075 (dihydrochloride). This product is intended for research and analytical applications. Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.
Product Specifications
CAS Number
173897-44-4
Target
Reference Standards; ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Others; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.[H]Cl.[H]Cl
Molecular Formula
C16H18Cl2N4O
Molecular Weight
353.25
References & Citations
[1]Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222|[2]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36 (10) :964-70.|[3]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55 (4) :411-7. Epub 2011 Jun 11.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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