GNF-PF-3777 (Standard)
GNF-PF-3777 (Standard) is the analytical standard of GNF-PF-3777 (HY-100687) . This product is intended for research and analytical applications. GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
Product Specifications
CAS Number
[77603-42-0]
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease
Smiles
O=C1N2C(C(C3=C2C=CC([N+]([O-])=O)=C3)=O)=NC4=CC=CC=C41
Molecular Formula
C15H7N3O4
Molecular Weight
293.23
References & Citations
[1]Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9.|[2]Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46 (3) :882-3.|[3]Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76 (3) :354-67.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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