(2R) -SR59230A (Standard)

(2R) -SR59230A (Standard) is the analytical standard of (2R) -SR59230A (HY-100672B) . This product is intended for research and analytical applications. (2R) -SR59230A is the isomer of SR59230A (HY-100672), and can be used as an experimental control. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2].

Product Specifications

CAS Number

[1932675-95-0]

Target

Others; Reference Standards

Related Pathways

Others

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

O[C@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.O=C(O)C(O)=O

Molecular Formula

C23H29NO6

Molecular Weight

415.48

References & Citations

[1]Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49 (1) :7-14.|[2]Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44 (11) :1141-7.|[3]Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39 (2) :368-384.|[4]Bexis S, et al. Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br J Pharmacol. 2009 Sep;158 (1) :259-66.