AZD5153 (6-Hydroxy-2-naphthoic acid) (Standard)

AZD5153 (6-Hydroxy-2-naphthoic acid) (Standard) is the analytical standard of AZD5153 (6-Hydroxy-2-naphthoic acid) (HY-100653A) . This product is intended for research and analytical applications. AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM.

Product Specifications

CAS Number

[1869912-40-2]

Target

Epigenetic Reader Domain; Reference Standards

Related Pathways

Epigenetics; Others

Field of Research

Cancer

Smiles

O=C(C1=CC=C2C=C(O)C=CC2=C1)O.O=C3N(C)CCN(CCOC4=CC=C(C5CCN(C6=NN7C(C=C6)=NN=C7OC)CC5)C=C4)[C@@H]3C

Molecular Formula

C36H41N7O6

Molecular Weight

667.75

References & Citations

[1]Rhyasen GW, et al. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 Nov;15 (11) :2563-2574.