APS-2-79 (Standard)

APS-2-79 (Standard) is the analytical standard of APS-2-79 (HY-100627) . This product is intended for research and analytical applications. APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].

Product Specifications

CAS Number

[2002381-25-9]

Target

MEK; Reference Standards

Related Pathways

MAPK/ERK Pathway; Others

Field of Research

Cancer

Smiles

CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=NC=NC4=CC(OC)=C(OC)C=C43

Molecular Formula

C23H21N3O3

Molecular Weight

387.43

References & Citations

[1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Aug 24;537 (7618) :112-116.