APS-2-79 (Standard)
APS-2-79 (Standard) is the analytical standard of APS-2-79. This product is intended for research and analytical applications. APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
Product Specifications
CAS Number
2002381-25-9
Target
MEK; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=NC=NC4=CC(OC)=C(OC)C=C43
Molecular Formula
C23H21N3O3
Molecular Weight
387.43
References & Citations
[1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Aug 24;537 (7618) :112-116.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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