AS1517499 (Standard)
AS1517499 (Standard) is the analytical standard of AS1517499. This product is intended for research and analytical applications. AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.
Product Specifications
CAS Number
919486-40-1
Target
Reference Standards; STAT
Related Pathways
JAK/STAT Signaling; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Cancer
Smiles
O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N
Molecular Formula
C20H20ClN5O2
Molecular Weight
397.86
References & Citations
[1]Nagashima S, et al. Synthesis and evaluation of 2-{[2- (4-hydroxyphenyl) -ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15 (2) :1044-55.|[2]Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41 (5) :516-24.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470177-100 1x 100 µL
CD50 (ICAM-3) (101-1D2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470149-500 1x 500 µL
CD106 / VCAM1 (1.4C3), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740352-500 1x 500 µL
CD31 / PECAM-1 (158-2B3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 