T16Ainh-A01 (Standard)

T16Ainh-A01 (Standard) is the analytical standard of T16Ainh-A01 (HY-100612) . This product is intended for research and analytical applications. T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 μM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) [1][2].

Product Specifications

CAS Number

[552309-42-9]

Target

Chloride Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Others

Smiles

O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)CSC3=NC(C)=C(CC)C(N3)=O

Molecular Formula

C19H20N4O3S2

Molecular Weight

416.52

References & Citations

[1]Fedigan S, et al. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Nov;469 (11) :1443-1455.|[2]Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286 (3) :2365-74.