T16Ainh-A01 (Standard)
T16Ainh-A01 (Standard) is the analytical standard of T16Ainh-A01. This product is intended for research and analytical applications. T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 μM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[2].
Product Specifications
CAS Number
552309-42-9
Target
Chloride Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Others
Smiles
O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)CSC3=NC(C)=C(CC)C(N3)=O
Molecular Formula
C19H20N4O3S2
Molecular Weight
416.52
References & Citations
[1]Fedigan S, et al. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Nov;469 (11) :1443-1455.|[2]Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286 (3) :2365-74.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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