CaCCinh-A01 (Standard)
CaCCinh-A01 (Standard) is the analytical standard of CaCCinh-A01. This product is intended for research and analytical applications. CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.
Product Specifications
CAS Number
407587-33-1
Target
Chloride Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=C(NC(C2=CC=CO2)=O)SC3=C1CCC(C(C)(C)C)C3)O
Molecular Formula
C18H21NO4S
Molecular Weight
347.43
References & Citations
[1]TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloridechannel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286 (3) :2365-74.|[2]De La Fuente R, et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloridechannel. Mol Pharmacol. 2008 Mar;73 (3) :758-68.|[3]Pin-Yi Liu, et al. TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke.Front Cell Neurosci. 2019 Aug 6;13:360.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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