(R) -GSK-F1

(R) -GSK-F1 is the R-type isomer of GSK-F1 (HY-100603) . GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research[1].

Product Specifications

CAS Number

[1384097-28-2]

UNSPSC

12352005

Target

Drug Isomer; PI3K; PI4K

Related Pathways

Others; PI3K/Akt/mTOR

Field of Research

Infection

Smiles

O=C1C2=C(N=C(N1C3=C(C(F)(F)F)C=CC=C3)N)C=CC(C4=CC(S(=O)(NC5=CC=C(C=C5F)F)=O)=C(OC)N=C4)=C2

Molecular Formula

C27H18F5N5O4S

Molecular Weight

603.52

References & Citations

[1]Bojjireddy N, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289 (9) :6120-32.