AS1842856 (Standard)
AS1842856 (Standard) is the analytical standard of AS1842856. This product is intended for research and analytical applications. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2].
Product Specifications
CAS Number
836620-48-5
Target
Autophagy; Reference Standards
Related Pathways
Autophagy; Others
Field of Research
Metabolic Disease
Smiles
O=C(C1=CN(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C1=O)O
Molecular Formula
C18H22FN3O3
Molecular Weight
347.38
References & Citations
[1]Nagashima T, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78 (5) :961-70.|[2]He J, et al. The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. Biosci Rep. 2019 May 10;39 (5) . pii: BSR20190112.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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