SirReal2 (Standard)
SirReal2 (Standard) is the analytical standard of SirReal2. This product is intended for research and analytical applications. SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration[1][2][3][4].
Product Specifications
CAS Number
709002-46-0
Target
Reference Standards; Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC1=NC=C(CC2=C3C=CC=CC3=CC=C2)S1)CSC4=NC(C)=CC(C)=N4
Molecular Formula
C22H20N4OS2
Molecular Weight
420.55
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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