3-O-Demethylfortimicin A

3-O-Demethylfortimicin A (A-49759) is an aminocyclitol antibiotic with antibacterial activity. 3-O-Demethylfortimicin A is particularly effective against Gram-negative pathogens and staphylococcus[1][2][3].

Product Specifications

CAS Number

[74842-47-0]

Product Name Alternative

A-49759

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

NCC(N(C)[C@@H]1[C@H]([C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2O[C@@H](CC[C@H]2N)[C@H](C)N)N)O)O)=O

Molecular Formula

C16H33N5O6

Molecular Weight

391.46

References & Citations

[1]Sennello LT, et al. Single-dose pharmacokinetics of 3-O-demethylfortimicin A in humans after intravenous and intramuscular administration. Antimicrob Agents Chemother. 1986 Mar;29 (3) :400-4.|[2]Girolami RL, et al. Comparative antimicrobial activity of O-demethylfortimicin A, a derivative of fortimicin A. Antimicrob Agents Chemother. 1980 Nov;18 (5) :766-72.|[3]Yang CL, et al. Comparative vestibular toxicity study with 3-O-demethylfortimicin A disulfate and gentamicin sulfate in cats. Drug Chem Toxicol. 1987;10 (3-4) :237-56.