Tie2 kinase inhibitor 1 (Standard)
Tie2 kinase inhibitor 1 (Standard) is the analytical standard of Tie2 kinase inhibitor 1. This product is intended for research and analytical applications. Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].
Product Specifications
CAS Number
948557-43-5
Target
Reference Standards; Tie
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2)C=C1)C
Molecular Formula
C26H21N3O2S
Molecular Weight
439.53
References & Citations
[1]Semones M, et al. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett. 2007 Sep 1;17 (17) :4756-60. Epub 2007 Jun 27.|[2]Hasenstein JR, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012 Feb;14 (2) :131-40.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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