(S) -Crizotinib (Standard)

(S) -Crizotinib (Standard) is the analytical standard of (S) -Crizotinib (HY-100549) . This product is intended for research and analytical applications. (S) -Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S) -Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models[1].

Product Specifications

CAS Number

[1374356-45-2]

Target

Apoptosis; DNA/RNA Synthesis; Reference Standards

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C

Molecular Formula

C21H22Cl2FN5O

Molecular Weight

450.34

References & Citations

[1]Huber KV, et al. Stereospecific targeting of MTH1 by (S) -crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508 (7495) :222-7.|[2]Dai X, et al. (S) -crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1. J Exp Clin Cancer Res. 2017 Sep 7;36 (1) :120.