(S) -Crizotinib (Standard)
(S) -Crizotinib (Standard) is the analytical standard of (S) -Crizotinib (HY-100549) . This product is intended for research and analytical applications. (S) -Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S) -Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models[1].
Product Specifications
CAS Number
[1374356-45-2]
Target
Apoptosis; DNA/RNA Synthesis; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
Molecular Formula
C21H22Cl2FN5O
Molecular Weight
450.34
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100549R/
Scientific Category
Reference Standards
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