GKI-1 (Standard)

GKI-1 (Standard) is the analytical standard of GKI-1 (HY-100521) . This product is intended for research and analytical applications. GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA[1].

Product Specifications

CAS Number

[2444764-03-6]

Target

Reference Standards; ROCK

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

ClC(C=C1)=CC=C1NC2=CC(C3=CNN=C3)=CC=C2

Molecular Formula

C15H12ClN3

Molecular Weight

269.73

References & Citations

[1]Ocasio CA, et al. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget. 2016 Nov 1;7 (44) :71182-71197.