(±) -Dehydroaltenusin
(±) -Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±) -Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±) -Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM) . (±) -Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±) -Dehydroaltenusin can be used for cancers like human adenocarcinoma research[1].
Product Specifications
CAS Number
34279-44-2
UNSPSC
12352005
Target
Antibiotic; Apoptosis; DNA/RNA Synthesis
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)C1(C)OC3=O
Molecular Formula
C15H12O6
Molecular Weight
288.25
References & Citations
[1]Mizushina Y, et al. Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α. Expert Opin Investig Drugs. 2011 Nov;20 (11) :1523-34.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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