RAF709 (Standard)
RAF709 (Standard) is the analytical standard of RAF709. This product is intended for research and analytical applications. RAF709 is a potent, selective, and efficacious RAF inhibitor with IC50s of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively[1]. Antitumor efficacy[1].
Product Specifications
CAS Number
1628838-42-5
Target
Raf; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C28H29F3N4O4
Molecular Weight
542.55
References & Citations
[1]Nishiguchi GA, et al. Design and Discovery of N- (2-Methyl-5'-morpholino-6'- ((tetrahydro-2H-pyran-4-yl) oxy) -[3,3'-bipyridin]-5-yl) -3- (trifluoromethyl) benzamide (RAF709) : A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J Med Chem. 2017 Jun 22;60 (12) :4869-4881.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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