NPS-1034 (Standard)

NPS-1034 (Standard) is the analytical standard of NPS-1034 (HY-100509) . This product is intended for research and analytical applications. NPS-1034 is a dual inhibitor of AXL and MET with IC50s of 10.3 and 48 nM, respectively.

Product Specifications

CAS Number

[1221713-92-3]

Target

Apoptosis; c-Met/HGFR; Reference Standards; TAM Receptor

Related Pathways

Apoptosis; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=C(C)N(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NC=C5C6=CC=CC=C6)=NC=C4)C(F)=C3

Molecular Formula

C31H23F2N5O3

Molecular Weight

551.54

References & Citations

[1]Rho JK, et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 2014 Jan 1;74 (1) :253-62.|[2]Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32 (3) :389-99.