ITSA-1 (Standard)

ITSA-1 (Standard) is the analytical standard of ITSA-1 (HY-100508) . This product is intended for research and analytical applications. ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA) -induced cell cycle arrest, histone acetylation, and transcriptional activation[1].

Product Specifications

CAS Number

[200626-61-5]

Target

HDAC; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Cancer

Smiles

O=C(N1N=NC2=CC=CC=C21)C3=CC=C(Cl)C=C3Cl

Molecular Formula

C13H7Cl2N3O

Molecular Weight

292.12

References & Citations

[1]Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10 (5) :397-410.|[2]Behera J, et al. Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. Sci Rep. 2018 Oct 15;8 (1) :15226.