Avadomide (Standard)
Avadomide (Standard) is the analytical standard of Avadomide. This product is intended for research and analytical applications. Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities[1][2][3].
Product Specifications
CAS Number
1015474-32-4
Product Name Alternative
CC 122 (Standard)
UNSPSC
12352005
Target
Apoptosis; E1/E2/E3 Enzyme; Molecular Glues; NF-κB; Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others; PROTAC
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O
Molecular Formula
C14H14N4O3
Molecular Weight
286.29
References & Citations
[1]Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126 (6) :779-89.|[2]Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25 (1) :90-98.|[3]Nishi H, et al., Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2023 Oct;92 (4) :303-314.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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