M2698 (Standard)
M2698 (Standard) is the analytical standard of M2698. This product is intended for research and analytical applications. M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity[1].
Product Specifications
CAS Number
1379545-95-5
Target
Akt; Reference Standards; Ribosomal S6 Kinase (RSK)
Related Pathways
MAPK/ERK Pathway; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N
Molecular Formula
C21H19ClF3N5O
Molecular Weight
449.86
References & Citations
[1]Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6 (4) :806-18.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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