BP-1-102 (Standard)

BP-1-102 (Standard) is the analytical standard of BP-1-102 (HY-100493) . This product is intended for research and analytical applications. BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.

Product Specifications

CAS Number

[1334493-07-0]

Target

Reference Standards; STAT

Related Pathways

JAK/STAT Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1O

Molecular Formula

C29H27F5N2O6S

Molecular Weight

626.59

References & Citations

[1]Zhang X, et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109 (24) :9623-8.|[2]De Simone V, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015 Jul;34 (27) :3493-503.