CP 122721
CP 122721 is an orally active NK1 receptor antagonist. CP 122721 attenuates cisplatin-induced vomiting in ferrets (ID50: 0.08 mg/kg) . CP 122721 inhibits kainate (KA) -induced seizure activity and CA1 neuronal cell death in rats. CP 122721 is useful in the study of depression, asthma, and irritable bowel syndrome (IBS) [1][2][3].
Product Specifications
CAS Number
145742-28-5
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
FC(F)(F)OC1=CC=C(OC)C(CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)=C1
Molecular Formula
C20H23F3N2O2
Molecular Weight
380.40
References & Citations
[1]Gonsalves S, et al. Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets. Eur J Pharmacol. 1996 Jun 3;305 (1-3) :181-5.|[2]Zachrisson O, Lindefors N, Brené S. A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity. Brain Res Mol Brain Res. 1998 Oct 1;60 (2) :291-5.|[3]Duffy RA. Potential therapeutic targets for neurokinin-1 receptor antagonists. Expert Opin Emerg Drugs. 2004 May;9 (1) :9-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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