KC-764
KC-764 is an orally active, reversible cyclooxygenase inhibitor with relative selectivity for platelet cyclooxygenase. KC-764 inhibits platelet thromboxane A2 (TXA2) production and platelet aggregation, with IC50s of 0.23 μM and 26 nM, respectively. KC-764 can be used for the research on antiplatelet and recurrence prevention in ischemic stroke[1].
Product Specifications
CAS Number
[94457-09-7]
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
O=C(C1=C2C=CC=CN2N=C1C)C3=CNCCC3
Molecular Formula
C14H15N3O
Molecular Weight
241.29
References & Citations
[1]Satoh K, et al. Pyrazolopyridine derivative acts as a novel cyclooxygenase inhibitor: antiplatelet effect in aged patients with ischemic stroke. J Am Geriatr Soc. 1994 Jun;42 (6) :639-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
TXA2/TP
Curated Selection
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