CPI-637 (Standard)
CPI-637 (Standard) is the analytical standard of CPI-637. This product is intended for research and analytical applications. CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP[1].
Product Specifications
CAS Number
1884712-47-3
Target
Epigenetic Reader Domain; Histone Acetyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
O=C1NC2=CC=CC(C3=CC4=C(N(C)N=C4C5=CN(C)N=C5)C=C3)=C2N[C@H](C)C1
Molecular Formula
C22H22N6O
Molecular Weight
386.45
References & Citations
[1]Taylor AM, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637) . ACS Med Chem Lett. 2016 Mar 15;7 (5) :531-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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